Anti-kanaka PLGF Antibody, Mouse Monoclonal

ʻIke Nui
ʻO ka preeclampsia (PE) kahi pilikia koʻikoʻi o ka hāpai ʻana i hōʻike ʻia e ke kiʻekiʻe a me ka proteinuria ma hope o 20 pule o ka hāpai ʻana.Loaʻa ka preeclampsia i ka 3-5% o nā hāpai ʻana a me ka hopena i ka nui o ka make a me ka maʻi maʻi makuahine a me ka hānai.Hiki ke ʻokoʻa nā hōʻike maʻi mai ka maʻalahi a i ke ʻano koʻikoʻi;ʻO ka preeclampsia kekahi o nā kumu nui o ka maʻi a me ka make o ka pēpē a me ka makuahine.

ʻIke ʻia ka preeclampsia ma muli o ka hoʻokuʻu ʻana o nā mea angiogenic mai ka placenta e hoʻoulu ai i ka hana endothelial.Hoʻololi ʻia nā pae serum o PlGF (placental growth factor) a me sFlt‑1 (soluble fms-like tyrosine kinase‑1, i ʻike ʻia ʻo soluble VEGF receptor‑1) i nā wahine me ka preeclampsia.Eia kekahi, hiki ke ho'okae ka pae o PlGF a me sFlt‑1 i ka hapai ma'amau mai ka preeclampsia ma mua o ka hiki 'ana mai o nā hō'ailona ma'i.I ka hapai maʻamau, piʻi ka pro-angiogenic factor PlGF i ka wā o nā trimesters mua ʻelua a emi iho i ka wā e hoʻomaka ai ka hāpai ʻana a hiki i ka manawa.I ka hoʻokaʻawale ʻana, paʻa mau nā pae o ka mea anti-angiogenic sFlt‑1 i ka wā mua a me ka waena waena o ka hāpai ʻana a piʻi mau a hiki i ka wā ʻōpiopio.I loko o nā wāhine e ulu ana i ka preeclampsia, ua ʻike ʻia he kiʻekiʻe o nā pae sFlt‑1 a ua ʻike ʻia he haʻahaʻa nā pae PlGF ma mua o ka hāpai ʻana maʻamau.