ʻIke Nui
Hoʻokaʻawale ʻia ʻo Alpha-fetoprotein (AFP) ma ke ʻano he lālā o ka albuminoid gene superfamily me ka albumin, AFP, ka protein vitamin D (Gc), a me ka alpha-albumin.ʻO ka AFP kahi glycoprotein o 591 amino acids a me kahi moiety carbohydrate.ʻO AFP kekahi o nā protein embryo-specific a he protein serum nui i ka hoʻomaka ʻana o ke ola embryonic kanaka e like me hoʻokahi mahina, i ka wā e loaʻa ai ka albumin a me ka transferrin i nā mea liʻiliʻi.Hoʻopili mua ʻia ia i loko o ke kanaka e ka ʻeke yolk a me ke ake (1-2 mahina) a ma hope o ka nui o ke ake.Hoʻopuka ʻia kahi hapa liʻiliʻi o AFP e ka ʻāpana GI o ka manaʻo kanaka.Ua hōʻike ʻia e hiki ke ʻike hou ʻia ka AFP i loko o ka serum i nā helu kiʻekiʻe i ke ola kanaka makua i hui pū me nā kaʻina hana hoʻihoʻi maʻamau a me ka ulu ʻino.ʻO ka alpha-fetoprotein (AFP) kahi hōʻailona kikoʻī no ka hepatocellular carcinoma (HCC), teratoblastomas, a me ka neural tube defect (NTD).
Manaʻo Pair | CLIA (Hopu-Hopu): 3C8-6 ~ 11D1-2 8A3-7 ~ 11D1-2 |
Maemae | >95%, hoʻoholo ʻia e SDS-PAGE |
ʻO ka hoʻopololei ʻana | PBS, pH7.4. |
Waihona | E mālama iā ia ma lalo o nā kūlana sterile ma -20℃a hiki i -80℃ma ka loaa ana. Manaʻo e hoʻokaʻawale i ka protein i nā mea liʻiliʻi no ka mālama maikaʻi ʻana. |
inoa mea kūʻai | Cat.ʻAʻole | Klone ID |
AFP | AB0069-1 | 11D1-2 |
AB0069-2 | 3C8-6 | |
AB0069-3 | 8A3-7 |
'Ōlelo Aʻo: Hiki i ka Bioantibody ke hoʻololi i ka nui o kāu pono.
1.Mizejewski GJ.(2001) Alpha-fetoprotein Structure and Function: Relevance to Isoforms, Epitopes, and Conformational Variants.Exp Biol Med.226(5): 377-408.
2.Tomasi TB, et al.(1977) Hoʻolālā a me ka hana o Alpha-Fetoprotein.Nānā Makahiki o Lapaʻau.28: 453-65.
3.Leguy MC, et al.(2011) Assessment of AFP in amniotic fluid: comparison of three automated techniques.Ann Biol Clin.69(4): 441-6.