Antibody MMP-3 Antibody, Monoclonal Mouse

ʻIke Nui
ʻO Matrix metallopeptidase 3 (i hoʻopau ʻia ʻo MMP3) ʻike ʻia ʻo stromelysin 1 a me progelatinase.He lālā ʻo MMP3 o ka ʻohana matrix metalloproteinase (MMP) nona nā lālā i komo i ka haki ʻana o ka matrix extracellular i nā kaʻina physiological maʻamau, e like me ka ulu ʻana o ka embryonic, ka hana hou ʻana, ka hoʻoponopono hou ʻana o ka ʻiʻo, a me nā kaʻina maʻi e pili ana i ka arthritis a me ka metastasis.Ma ke ʻano he endopeptidase pili i ka zinc, hoʻohana ʻo MMP3 i kāna mau hana ma ka matrix extracellular.Hoʻohana ʻia kēia pūmua e ʻelua mau mea hoʻopaneʻe endogenous nui: alpha2-macroglobulin a me nā mea paʻa ʻiʻo o nā metalloproteases (TIMPs).He koʻikoʻi ko MMP3 i ka hoʻohaʻahaʻa ʻana i nā ʻano collagen II, III, IV, IX, a me X, proteoglycans, fibronectin, laminin, a me ka elastin.Hiki nō hoʻi, hiki i ka MMP3 ke hoʻoikaika i nā MMP ʻē aʻe e like me MMP1, MMP7, a me MMP9, e hoʻolilo ana i ka MMP3 i mea koʻikoʻi i ka hoʻoponopono hou ʻana o ka ʻiʻo pili.Ua hoʻopili ʻia ka Dysregulation o MMP i nā maʻi he nui e like me ka ʻāʻī ʻana, ka maʻi ʻeha mau, ka encephalomyelitis, a me ka maʻi kanesa.ʻO nā mea hoʻopaneʻe kūlohelohe a kūlohelohe paha o MMP ka hopena i ka pale ʻana i ka metastasis, ʻoiai ka hoʻoponopono ʻana o nā MMP i alakaʻi i ka hoʻonui ʻia ʻana o ka maʻi kanesa.