He ma'i bacteria 'o Helicobacter pylori (HP) e noho ana i loko o ka 'ōpū a pili i ka mucosa 'ōpū a me nā wahi intercellular, e ho'oulu ai i ka mumū.ʻO ka maʻi HP kekahi o nā maʻi bacteria maʻamau, e hoʻopilikia ana i nā piliona kānaka a puni ka honua.ʻO lākou ke kumu nui o ka maʻi ʻeha a me ka gastritis (ka wela o ka ʻōpū o ka ʻōpū).

ʻO ka maʻi kiʻekiʻe o nā keiki a me ka hui ʻohana nā hiʻohiʻona koʻikoʻi o ka maʻi HP, a ʻo ka lawe ʻana paha i ka ʻohana ke ala nui ʻo ka maʻi HP ka kumu kumu nui o ka maʻi maʻi maʻi maʻi maʻi maʻi maʻi peptic, maʻi maʻi o ka ʻōpū e pili ana i ka lymphoid tissue (MALT) lymphoma, a maʻi maʻi ʻōpū.I ka makahiki 1994, ua koho ka World Health Organization/International Agency for Research on Cancer (WHO/IARC) i ka Helicobacter pylori ma ke ʻano he carcinogen papa I.

ʻO Gastric mucosa - ka pale kino o ka ʻōpū

Ma lalo o nā kūlana maʻamau, loaʻa i ka pā o ka ʻōpū kahi ʻano o nā ʻano hana palekana ponoʻī (ka huna ʻana o ka waikawa gastric a me ka protease, ka pale ʻana i nā ʻāpana mucus insoluble a me ka soluble, hoʻomaʻamaʻa maʻamau, a me nā mea ʻē aʻe), hiki ke pale aku i ka hoʻouka ʻana o nā tausani microorganisms. e komo ana ma ka waha.

Loaʻa iā HP ka flagella kūʻokoʻa a me kahi hoʻolālā helical kūʻokoʻa, ʻaʻole wale ia e hoʻokani i ka hana heleuma i ka wā o ka colonization bacteria, akā hiki ke lilo i spherical a hana i kahi morphology pale ponoʻī i nā wahi paʻakikī.I ka manawa like, hiki i ka Helicobacter pylori ke hana i nā ʻano meaʻawaʻawa, kahi e hoʻoholo ai e hiki i ka Helicobacter pylori ke hele i loko o ka papa wai o ka ʻōpū ma o kona mana ponoʻī a kūʻē i ka waikawa gastric a me nā mea maikaʻi ʻole ʻē aʻe, e lilo i microorganism hiki ke ola i loko o ka ʻōpū o ke kanaka. .

Pathogenesis o Helicobacter pylori

1. Laikini

Ua hōʻike ʻia nā haʻawina he ikaika ikaika ʻo Helicobacter pylori e neʻe i loko o kahi ʻano viscous, a pono ka flagella no ka ʻauʻau bacteria e ʻauʻau i ka pale mucus pale ma ka ʻili o ka ʻōpū o ka ʻōpū.

2. ʻO ka pūmua A (CagA) e pili ana i ka endotoxin a me ka ʻawaʻawa vacuolar (VacA)

ʻO ka pūmua A (CagA) pili i ka cytotoxin i hūnā ʻia e HP hiki ke hoʻoulu i ka pane inflammatory kūloko.ʻO ka maʻi Helicobacter pylori maikaʻi ʻo CagA hiki ke hoʻonui nui i ka pilikia o ka gastritis atrophic, metaplasia ʻōpū a me ka maʻi maʻi ʻōpū.

ʻO ka vacuolating cytotoxin A (VacA) kekahi kumu pathogenic nui loa o Helicobacter pylori, hiki ke komo i ka mitochondria e hoʻoponopono i ka hana o nā organelles.

3. Ka hae hae

ʻElua mau protein flagellin, FlaA a me FlaB, nā mea nui o nā filament flagellar.Hoʻololi nā hoʻololi o ka flagellin glycosylation i ka motility strain.I ka hoʻonui ʻia ʻana o ke kiʻekiʻe o ka flaA protein glycosylation, ua hoʻonui ʻia ka hiki ke neʻe a me ka ukana colonization o ke kānana.

4. Urease

Hoʻopuka ʻo Urease i ka NH3 a me CO2 ma o ka hydrolyzing urea, ka mea e hoʻokaʻawale i ka ʻakika ʻōpū a hoʻonui i ka pH o nā cell a puni.Eia kekahi, komo ka urease i nā pane inflammatory a hoʻoikaika i ka hoʻopili ʻana ma o ka launa pū ʻana me nā mea hoʻokipa CD74 ma nā cell epithelial gastric.

5. Puka wela HSP60/GroEL

Hoʻopili ʻo Helicobacter pylori i ke ʻano o nā protein haʻalulu wela i mālama nui ʻia, ʻo ia ka co-expression o Hsp60 me ka urease ma E. coli e hoʻonui nui i ka hana urease, e ʻae ana i ka pathogen e hoʻololi a ola i loko o ka niche ecological enemi o ka ʻōpū o ke kanaka.

6. Pilikia pili Hook 2 homolog FliD

ʻO FliD kahi pūmua hana e pale ai i ka piko o ka flagella a hiki ke hoʻokomo pinepine i ka flagellin e ulu ai i nā filament flagellar.Hoʻohana ʻia ʻo FliD ma ke ʻano he mole adhesion, e ʻike ana i nā molekole glycosaminoglycan o nā pūnaewele host.I loko o nā pūʻali maʻi, nā anti-flid antibodies nā hōʻailona o ka maʻi a hiki ke hoʻohana ʻia no ka maʻi serological.

Nā ʻano hoʻāʻo:

1. Ka ho'āʻo ʻana o ka pahu: ʻO ka hoʻāʻo antigen stool kahi hoʻāʻo non-invasive no H. pylori.He palekana ka hana, maʻalahi a me ka wikiwiki, ʻaʻole koi i ka hoʻoponopono waha o nā reagents.

2. Ka ʻike ʻana i ka maʻi antibody: Ke loaʻa ka maʻi Helicobacter pylori i loko o ke kino, e loaʻa i ke kino o ke kanaka nā antibodies anti-Helicobacter pylori i loko o ke koko ma muli o kahi pane pale.Ma ke kiʻi ʻana i ke koko e nānā i ka ʻike o nā antibodies Helicobacter pylori, hiki iā ia ke noʻonoʻo inā he Helicobacter pylori i loko o ke kino.maʻi bacteria.

3. ʻO ka hoʻāʻo ʻana i ka hanu: He ʻano loiloi kaulana kēia i kēia manawa.ʻO ka urea waha i loaʻa ka 13C a i ʻole 14C, a e hoʻāʻo ka hanu i ka neʻe ʻana o ka carbon dioxide i loaʻa ka 13C a i ʻole 14C ma hope o kekahi manawa, no ka mea inā he Helicobacter pylori, e ʻike ʻia ka urea e kāna urea kikoʻī.Hoʻohaʻahaʻa nā enzymes i ka amonia a me carbon dioxide, kahi i hoʻokuʻu ʻia mai ka māmā ma o ke koko.

4. Endoscopy: hiki ke nānā pono i nā hiʻohiʻona mucosal ʻōpū e like me ka ʻulaʻula, ka pehu, nā loli nodular, etc.;ʻAʻole kūpono ka endoscopy no nā poʻe maʻi me nā pilikia koʻikoʻi a i ʻole contraindications a me nā kumukūʻai hou (anesthesia, forceps) ).

Nā huahana pili bioantibody o H.pyloriʻōlelo paipai:

H. Pylori Antigen Rapid Test Kit (Lateral Chromatography)

H. Pylori Antibody Rapid Test Kit (Lateral Chromatography)