Antibody TIMP1 kanaka, Monoclonal Mouse
Nā kikoʻī huahana
ʻIke Nui
ʻO TIMP metallopeptidase inhibitor 1, i ʻike ʻia ʻo TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced protein Tissue inhibitor of metalloproteinases 1, he mea hoʻopaneʻe kūlohelohe o ka matrix metalloproteinases (MMPs), he hui o nā peptidases. pili i ka hoʻohaʻahaʻa ʻana i ka matrix extracellular.Loaʻa ka TIMP-1/TIMP1 i loko o nā ʻiʻo fetal a me nā pākeke.Loaʻa nā pae kiʻekiʻe ma ka iwi, ka māmā, ka ovary a me ka ʻōpū.ʻO nā paʻakikī me nā metalloproteinases a hoʻihoʻi ʻole iā lākou ma ka hoʻopaʻa ʻana i kā lākou cofactor zinc catalytic.Hoʻopili ʻo TIMP-1/TIMP1 i ka erythropoiesis in vitro;akā, ʻaʻole like me IL-3, he ʻano-specific, hoʻoulu i ka ulu a me ka ʻokoʻa o nā progenitors erythroid kanaka a me murine wale nō.Ma waho aʻe o kāna hana pale e kū'ē i ka hapa nui o nā MMP i ʻike ʻia, hiki i ka protein ke hoʻoikaika i ka hoʻonui ʻana o ka cell i kahi ākea o nā ʻano cell, a loaʻa paha kahi hana anti-apoptotic.ʻO ka unuhi ʻana o kēia ʻano hoʻopulapula protein i hiki ke pane i nā cytokines a me nā hormones.Eia kekahi, ʻo ka ʻōlelo mai kekahi akā ʻaʻole nā X chromosomes pau ʻole e hōʻike ana he polymorphic kēia gene inactivation i nā wahine kanaka.Aia kēia gene encoding i loko o ka intron 6 o ka gene synapsin I a ua unuhi ʻia ma ka ʻaoʻao ʻē aʻe.ʻO nā paʻakikī me nā metalloproteinases a hoʻihoʻi ʻole iā lākou ma ka hoʻopaʻa ʻana i kā lākou cofactor zinc catalytic.ʻIke ʻia ʻo TIMP-1/TIMP1 e hana ma MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 a MMP-16.
Waiwai
| Manaʻo Pair | CLIA (Hopu-Hopu): 1D5-5 ~ 3G11-6 1D12-2 ~ 1G3-7 |
| Maemae | >95% e like me ka mea i hoʻoholo ʻia e SDS-PAGE. |
| ʻO ka hoʻopololei ʻana | PBS, pH7.4. |
| Waihona | E mālama iā ia ma lalo o nā kūlana sterile ma -20 ℃ a -80 ℃ ma ka loaʻa ʻana. Manaʻo e hoʻokaʻawale i ka protein i nā mea liʻiliʻi no ka mālama maikaʻi ʻana. |
Hoʻohālikelike hoʻokūkū
ʻIke Kauoha
| inoa mea kūʻai | Cat.ʻAʻole | Klone ID |
| TIMP1 | AB0034-1 | 1D5-5 |
| AB0034-2 | 1D12-2 | |
| AB0034-3 | 1G3-7 | |
| AB0034-4 | 3G11-6 |
'Ōlelo Aʻo: Hiki i ka Bioantibody ke hoʻololi i ka nui o kāu pono.
Kuhikuhi
1.Barylski M, Kowalczyk E, Szadkowska I, et al.[Ka mea hoʻopaʻa paʻi o nā metalloproteinases[J].Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego, 2011, 30(178):246-8.
2. Hayakawa T , Yamashita K , Tanzawa K , et al.ʻO ka hana hoʻoikaika i ka ulu ʻana o ka mea hoʻopaneʻe ʻiʻo o nā metalloproteinases-1 (TIMP-1) no kahi ākea ākea He mea ulu hou i ka serum [J].Nā Leta FEBS, 1992, 298.
3.Haider DG, Karin S, Gerhard P, et al.Hoʻemi ʻia ka serum retinol-binding protein 4 ma hope o ka lilo ʻana o ke kaumaha ma nā mea momona momona.[J].Nūpepa o Clinical Endocrinology & Metabolism(3):1168-71.
