Antibody CHI3L1 kanaka, Monoclonal kanaka

ʻIke Nui
ʻO Chitinase-3-like protein 1 (CHI3L1) kahi mea huna heparin-binding glycoprotein nona ka ʻōlelo e pili ana me ka neʻe ʻana o nā ʻiʻo maʻemaʻe vascular.Hōʻike ʻia ka CHI3L1 ma nā pae kiʻekiʻe ma nā moʻomeheu VSMC nodular postconfluent a ma nā pae haʻahaʻa i nā moʻomeheu subconfluent proliferating.ʻO ka CHI3L1 he lectin i hoʻopaʻa ʻia i ka ʻiʻo, chitin-binding lectin a me ka lālā o ka ʻohana glycosyl hydrolase 18. ʻAʻole like me nā māka monocyto / macrophage ʻē aʻe, ʻaʻole i loaʻa kona hōʻike i loko o nā monocytes a ikaika i hoʻoulu ʻia i ka wā hope o ka hoʻokaʻawale ʻana o ka macrophage kanaka.Hoʻopili ʻia nā pae kiʻekiʻe o CHI3L1 me nā maʻi e hōʻike ana i ka piʻi ʻana o ka ʻiʻo pili, e like me ka rheum atoid, arthritis, osteoarthritis, scleroderma, a me cirrhosis o ke ake, akā ua hana ʻia ma ka cartilage mai nā mea hāʻawi kahiko a i ʻole nā ​​​​maʻi me ka osteoarthritis.Hōʻike ʻole ʻia ʻo CHI3L1 i ka hippocampus o nā poʻe me ka schizophrenia a hiki ke komo i ka pane kelepona i nā hanana kaiapuni like ʻole i hōʻike ʻia e hoʻonui i ka pilikia o ka schizophrenia.