Anti-kanaka Her2 Antibody, Mouse Monoclonal

ʻIke Nui
ʻO ke kanaka epidermal growth factor receptor 2 (HER2), i ʻike ʻia ʻo ErbB2, NEU, a me CD340, he ʻano I membrane glycoprotein a no ka ʻohana receptor epidermal growth factor (EGF).ʻAʻole hiki i ka protein HER2 ke hoʻopaʻa i nā mea ulu ma muli o ka nele o ka ligand binding domain nona iho a autoinhibited constitutively.Eia nō naʻe, hoʻokumu ʻo HER2 i heterodimer me nā lālā o ka ʻohana EGF receptor ligand, no laila e hoʻopaʻa i ka ligand paʻa a hoʻonui i ka hoʻoulu ʻana o ka kinase-mediated o nā molekole lalo.He kuleana koʻikoʻi ka HER2 i ka hoʻomohala ʻana, ka hoʻonui ʻana o ka cell a me ka ʻokoʻa.Ua hōʻike ʻia ʻo HER2 gene e pili pū me ka maʻi maʻi a me ka wānana maikaʻi ʻole i nā maʻi maʻi maʻi he nui, e like me ka umauma, prostate, ovarian, maʻi maʻi pūmāmā a pēlā aku.